GASTROINTESTINAL ACID-RELATED DISEASES AND ISCHEMIC HEART DISEASE: PATHOPHYSIOLOGICAL LINKS AND CLINICAL IMPLICATIONS
Keywords:
Keywords: Comorbidity, gastroesophageal reflux disease, ischemic heart disease, dual antiplatelet therapy, anticoagulants, aminosalicylates.Abstract
Аnnotation. This review summarizes key evidence on the interrelations
between gastroesophageal reflux disease, peptic ulcer disease, liver disorders,
inflammatory bowel diseases, and ischemic heart disease. It highlights both
common and specific risk factors, as well as mechanisms of comorbidity,
including those linked to standard treatments. Based on meta-analyses and large-
scale population studies, the review aims to support the improvement of current
clinical guidelines for managing comorbid conditions.
References
1. Wunker C. The diagnosis and treatment of peptic ulcer disease and its
complications: a review. Consultant. 2018; 58(1):10–16.
2. Glassner K.L., Abraham B. P., Quigley E. M.M. The microbiome and infl
ammatory bowel disease. J Allergy Clin Immunol. 2020 Jan;145(1):16–27. doi:
10.1016/j. jaci.2019.11.003.
3. Goldstone R.N., Steinhagen R. M. Abdominal Emer gencies in
Inflammatory Bowel Disease. SurgClin North Am. 2019 Dec; 99(6):1141–1150. doi:
10.1016/j.suc.2019.08.007.
4. Simonova Zh.G., Martusevich A. K., Tarlovskaia E. I. The course of
coronary heart disease concurrent with peptic ulcer disease: Clinical and pathogenetic
aspects. Terapevticheskii Arkhiv. 2014;86(1):33–36. (In Russ.)
5. Shiraev TP, Bullen A. Proton Pump Inhibitors and Cardiovascular Events:
A Systematic Review. Heart Lung Circ. 2018 Apr;27(4):443–450. doi: 10.1016/j.
hlc.2017.10.020.
