MODERN TECHNOLOGIES FOR DIFFERENTIAL DIAGNOSIS OF LARGE B-CELL LYMPHOMAS
Keywords:
Key words: Diffuse large B-cell lymphoma (DLBCL); Immunohistochemistry (IHC); Molecular profiling; Flow cytometry; PET/CT, imaging; Artificial intelligence; Differential diagnosis; WHO classification; Biomarkers; Precision oncology.Abstract
Annotation: Large B-cell lymphomas (LBCLs) are a heterogeneous group of
non-Hodgkin lymphomas that originate from B-lymphocytes and exhibit diverse
clinical, morphological, and molecular characteristics. Accurate differential
diagnosis of LBCL subtypes often exceeds the capabilities of conventional
histopathological methods alone. Therefore, modern diagnostic technologies —
including immunohistochemistry, flow cytometry, molecular and genetic profiling,
advanced imaging techniques (such as PET/CT), and artificial intelligence-based
algorithms are increasingly being utilized in clinical practice. This article reviews
the role, applications, and advantages of these contemporary approaches in
improving the precision of differential diagnosis in large B-cell lymphomas,
supported by the latest scientific literature.
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