POST-COVID-19 OSTEOPOROSIS: EMERGING CHALLENGES AND THERAPEUTIC PERSPECTIVES
Keywords:
Key words. COVID-19, osteoporosis, post-COVID syndrome, bone loss, cytokine storm, corticosteroids, vitamin D deficiency, bone mineral density, fracture risk, bone metabolismAbstract
Abstract. The COVID-19 pandemic, beyond its acute respiratory effects, has led to a wave of long-term complications, including a notable increase in post-infection osteoporosis. Recent studies suggest that SARS-CoV-2 disrupts bone remodelling processes via immune dysregulation, cytokine storms, and prolonged immobilization. Furthermore, corticosteroid therapy and reduced physical activity during recovery exacerbate bone demineralization. This article explores the pathophysiological mechanisms, clinical consequences, and therapeutic strategies for managing post-COVID-19 osteoporosis. Understanding these interlinked processes is vital for early intervention and preventing fractures in vulnerable populations, especially the elderly and chronically ill. Timely diagnosis, rehabilitation programs, and targeted pharmacological treatments could help mitigate the burden of this emerging skeletal health crisis.
