THREE-DIMENSIONAL VISUALIZATION AND MORPHOMETRIC ANALYSIS OF THE DEVELOPING FETAL BRAIN USING MRI AND DIGITAL RECONSTRUCTION

Abstract

Advancements in magnetic resonance imaging (MRI) and digital reconstruction have revolutionized fetal neuroimaging by providing high-resolution, non-invasive insights into the developing brain. This study aimed to analyze the morphometric growth patterns and structural organization of the fetal brain in different gestational stages through three-dimensional (3D) visualization and measurement using MRI and digital modeling. A cohort of 50 fetuses between 18 to 36 weeks of gestation was studied. T2-weighted MRI sequences were acquired, segmented, and reconstructed using digital software for volumetric and surface analysis. Significant trends in brain volume, cortical folding, and structural asymmetry were observed across gestational weeks. The findings underscore the utility of 3D morphometric analysis in understanding fetal neurodevelopment and detecting early anomalies.