CLINICAL MANAGEMENT OF RHEUMATOID ARTHRITIS DURING PREGNANCY: CHALLENGES AND THERAPEUTIC APPROACHES
Ключевые слова:
Rheumatoid arthritis, pregnancy, disease-modifying antirheumatic drugs (DMARDs), biologic therapies, non-steroidal anti-inflammatory drugs (NSAIDs), drug safety, maternal health, fetal health, clinical management, therapeutic approaches, non-pharmacological interventions.Аннотация
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that primarily affects the joints, leading to inflammation, pain, and long-term damage. The management of RA during pregnancy presents unique challenges due to the need to balance effective disease control with the safety of both the mother and the developing fetus. This review explores the clinical management of rheumatoid arthritis in pregnant women, focusing on the therapeutic approaches, drug safety, and potential risks associated with various treatments. The use of disease-modifying antirheumatic drugs (DMARDs), non-steroidal anti-inflammatory drugs (NSAIDs), and biologic therapies is critically evaluated in the context of pregnancy, with particular emphasis on their safety profiles and the impact on maternal and fetal health. The review also discusses non-pharmacological interventions, including physical therapy and lifestyle modifications, as adjuncts to pharmacological treatments. Understanding the complexities of managing RA during pregnancy is essential for clinicians to optimize patient care and improve pregnancy outcomes.
