YANGI AVLOD ANTIBIOTIKLARINI QO`LLANILISHI
Keywords:
Kalit so‘zlar: yangi avlod antibiotiklari, farmakologiya, rezistentlik, infeksiya, dorivor preparatlar.Abstract
Annotatsiya: Ushbu maqolada yangi avlod antibiotiklarining qo‘llanilish sohalari, ularning afzalliklari va samaradorligi tahlil qilinadi. Antibiotiklar rivojlanishi jarayoni va ularning farmakologik xususiyatlari haqida ma’lumotlar keltirilgan. Tadqiqot natijalari yangi avlod antibiotiklarining mikroorganizmlarga qarshi kurashishdagi ahamiyatini ochib beradi.
References
1. Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Lancet 2022, 399, 629–655. [CrossRef] [PubMed]
2. Hutchings, M.I.; Truman, A.W.; Wilkinson, B. Antibiotics: Past, present and future. Curr. Opin. Microbiol. 2019, 51, 72–80. [CrossRef] [PubMed]
3. Qin, Z.; Munnoch, J.T.; Devine, R.; Holmes, N.A.; Seipke, R.F.; Wilkinson, K.A.; Wilkinson, B.; Hutchings, M.I. Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants. Chem. Sci. 2017, 8, 3218–3227. [CrossRef]
4. Saha, S.; Zhang, W.; Zhang, G.; Zhu, Y.; Chen, Y.; Liu, W.; Yuan, C.; Zhang, Q.; Zhang, H.; Zhang, L.; et al. Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams. Chem. Sci. 2017, 8, 1607–1612. [CrossRef]
5. Saha, S.; Zhang, W.; Zhang, G.; Zhu, Y.; Chen, Y.; Liu, W.; Yuan, C.; Zhang, Q.; Zhang, H.; Zhang, L.; et al. Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams. Chem. Sci. 2017, 8, 1607–1612. [CrossRef]
6. Breijyeh, Z.; Jubeh, B.; Karaman, R. Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It. Molecules 2020, 25, 1340. [CrossRef]
7. Lepore, C.; Silver, L.; Theuretzbacher, U.; Thomas, J.; Visi, D. The small-molecule antibiotics pipeline: 2014–2018. Nat. Rev. Drug Discov. 2019, 18, 739–740. [CrossRef]
8. WorldHealth Organization. Antibacterial Agents in Clinical and Preclinical Development: An Overview and Analysis; World Health Organization: Geneva, Switzerland, 2021.
