MORPHOLOGICAL VARIANTS OF THE CIRCLE OF WILLIS AND THEIR ROLE IN ISCHEMIC STROKE RISK

Авторы

  • Davronov U.T. Автор

Аннотация

Abstract: The Circle of Willis is a crucial arterial anastomosis located at the base of the brain. It ensures redundancy in cerebral circulation, maintaining perfusion in case of vascular occlusion. However, only a minority of individuals have a complete and symmetric Circle of Willis. The high prevalence of morphological variants—such as hypoplasia or absence of component arteries—may compromise cerebral collateral capacity. This article reviews the anatomical configurations of the Circle of Willis, evaluates their embryological origins, and explores their implications in ischemic stroke vulnerability.

Библиографические ссылки

1. Kapoor K, Singh B, Dewan LI. Variations in the configuration of the Circle of Willis. Anat Sci Int. 2008;83(2):96–106.

2. Krabbe-Hartkamp MJ et al. Circle of Willis: Morphologic variation on MR angiograms. Radiology. 1998;207(1):103–111.

3. Van Raamt AF, Mali WP, van Laar PJ, van der Graaf Y. The fetal variant of the Circle of Willis and its influence on cerebral collateral circulation. Cerebrovasc Dis. 2006;22(4):217–224.

4. Hartkamp MJ et al. Circle of Willis collateral flow investigated by magnetic resonance angiography. Stroke. 1999;30(12):2671–2678.

5. Alpers BJ, Berry RG. Circle of Willis in cerebral vascular disorders: anatomical variations. JAMA. 1963;185(8):882–885.

6. Vrselja Z, Brkic H, Mrdenovic S. Function of the Circle of Willis. J Cereb Blood Flow Metab. 2014;34(4):578–584.

7. Chen HW et al. The effect of Circle of Willis anatomical variations on ischemic stroke: A meta-analysis. Neuroradiology. 2020;62(6):665–673.

8. Shoja MM, Tubbs RS. Anatomy and function of the Circle of Willis. Clin Anat. 2007;20(3):298–302.

9. Qiu C, Winblad B, Fratiglioni L. Circle of Willis and risk of ischemic stroke in the elderly. Stroke. 2003;34(8):1790–1795.

10. Macchi C, Catini C, Federico C. MR angiographic evaluation of the Circle of Willis. Ital J Anat Embryol. 1996;101(2):115–123.

Опубликован

2025-06-28

Как цитировать

Davronov U.T. (2025). MORPHOLOGICAL VARIANTS OF THE CIRCLE OF WILLIS AND THEIR ROLE IN ISCHEMIC STROKE RISK. JOURNAL OF NEW CENTURY INNOVATIONS, 79(2), 244-246. https://scientific-jl.com/new/article/view/23611