STRUCTURAL AND FUNCTIONAL BRAIN ALTERATIONS AS TRIGGERS OF ISCHEMIC STROKE IN COVID-19 PATIENTS

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  • Kazakov Bekzod Shodiyorovich ##default.groups.name.author##

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Keywords: COVID-19, ischemic stroke, brain function, neurological complications, structural changes, neurovascular events.

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Abstract. Stroke remains one of the major causes of long-term disability worldwide, significantly impairing motor abilities, sensory perception, and emotional-cognitive functions. By the end of the acute phase, approximately 85% of stroke survivors experience persistent motor dysfunction and speech disturbances such as aphasia. In some individuals infected with COVID-19, the onset of acute ischemic stroke may be linked to specific structural and functional alterations in the brain. This article explores the possible mechanisms by which COVID-19-related neurological changes contribute to stroke development.

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1. Grabowska-Fudala B., Jaracz K., Gуrna K. Stroke incidence, case fatality and mortality--current trends and future prognosis // Przegl. Epidemiol. — 2010. — №3. — Р. 439-442.

2. Hassoun H.T., Malas M.B., Freischlag J.A. Secondary stroke prevention in the era of carotid stenting: update on recent trials // Arch. Surg. — 2010. — №10. — Р.928-935.

3. Kaste M. Every day is a world stroke day: act now, be a stroke champion and a torchbearer! // Stroke. — 2010. — №11. — Р. 2449-2250.

4. Mirakramovna Y. M. et al. Covid-19 dan keyin rivojlangan miyelitlar //образование наука и инновационные идеи в мире. – 2025. – Т. 63. – №. 2. – С. 396-400.

5. Yakubova M. M., Madaminova S. A. Semizlik va uyqu buzilishini klinik-nevrologik va neyrofiziologik jihatdan bog'liqligini o'rganish //Журнал гуманитарных и естественных наук. – 2025. – №. 20. – С. 123-125.

6. Mirakramovna Y. M. et al. Bosh miya qon tomir anomaliyalarining serebrovaskulyar kasalliklarni kelib chiqishidagi ahamiyati //образование наука и инновационные идеи в мире. – 2025. – Т. 63. – №. 2. – С. 401-405.

7. Ostrovaya T.V., Cherniy V.I. Cerebroprotection in the aspect of evidence-based medicine // Medicine of emergency conditions. - 2007. - No. 2. - S. 48-53.

8. Shodiyorovich K. B., Tadjiyevna K. D. Clinical rehabilitation of patients with cerebral stroke caused by a stroke with COVID-19 //European Journal of Molecular & Clinical Medicine. – 2021. – Т. 8. – №. 1. – С. 1446-1451.

9. Ginsberg M.D. Adventures in pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection. The Thomas Willis lecture // Stroke. — 2003. — №1. — Р. 214-223.

10. Cherniy V.I., Elskiy V.N., Gorodnik G.A. et al. Acute cerebral insufficiency. - Donetsk: Izd. Zaslavsky A.Yu., 2008 .-- 440 p.

11. Shtark MB Brain-specific proteins (antigens) and neuron function. - M .: Medicine, 1989.

12. Kong D.F., Topol E.J., Bittl J.A. et al. Clinical outcomes of bivalirudin for ischemic heart disease // Circulation. — 1999. — №100. – Р. 2049-2053.

##submissions.published##

2025-06-19