MOLECULAR-GENETIC ANALYSIS OF THE CAUSES OF TERMINAL CUTANEOUS LEISHMANIOSIS IN THE SAMARKAND DISTRICT OF SAMARKAND REGION
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Kalit so‘zlar: Teri leyshmaniozi, antroponoz, zoonoz, epidemiologik, parazit, polimeraza zanjiri reaktsiyasi (PZR).##article.abstract##
Annotatsiya: O‘zbekistoning ko‘plab hududlarida, xususan, Samarqand viloyatining ko‘plab tumanlarida teri leyshmaniozi bilan kasallanish kuzatiladi. Teri leyshmaniozi qo‘zg‘atuvchilari odam organizmiga tashuvchilar orqali tushgach, uzoq vaqt davomida tuzalmaydigan yaralarni hosil qiladi. Kasallik qo‘zg‘atuvchining turiga qarab antroponoz teri leyshmaniozi (ATL) va zoonoz teri leyshmaniozi (ZTL) turlariga bo‘linadi. Teri leyshmaniozi yaralarini davolashda, kasallikning epidemiologik xaritasini tuzishda, tashxislash usullarini takomillashtirishda leyshmaniya turlarini (L.tropica, L.major) aniqlash muhumdir. O‘zbekistonda leyshmanioz yaralaridagi leishmaniya turlarini aniqlashga oid tadqiqotlar yetarlicha emas. Kasallik umumiy tashxislash usulida amalga oshiriladi va uni davolashda alohida usullardan foydalanilmaydi. Teri leyshmaniozi yaralarini molekulyar-genetik jihatdan tahlil qilish, davolash va epidemiologiyaga oid muammolarni hal qilish bilan birga, ilmiy yangilik bo‘lib hisoblanadi. Ushbu tadqiqotlarda eng samarali usul polimeraza zanjiri reaktsiyasidir (PZR).
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