"THE RISING INCIDENCE OF COLORECTAL CANCER IN YOUNG ADULTS"
Ключевые слова:
Risk factors include both non-modifiable and modifiable contributors. Genetic predispositions such as Lynch syndrome, familial adenomatous polyposis (FAP), and MUTYH-associated polyposis are major inherited contributors. On the modifiable side, high intake of processed and red meats, low dietary fiber, sedentary lifestyle, obesity, smoking, and excessive alcohol consumption are strongly linked. Recent research also points to early-life antibiotic exposure and dysbiosis (imbalance) of gut microbiota as emerging risk factors. Inflammatory bowel diseases (IBD), includingCrohn's disease and ulcerative colitis, significantly increase CRCi risk if untreated.Аннотация
Colorectal cancer (CRC) has traditionally been considered a disease affecting
older adults. However, recent studies have shown a disturbing rise in CRC incidence
among individuals under 50 years of age. This article explores the epidemiological
trends, risk factors, clinical presentation, and the importance of early detection
strategies in young adults. Additionally, it evaluates the role of genetic predispositions,
lifestyle factors, and diagnostic challenges that contribute to late-stage discovery in
younger populations.
Библиографические ссылки
1. American Cancer Society. Colorectal Cancer Facts & Figures 2023.
2. Siegel RL, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin.
3. Araghi M, et al. Global trends in colorectal cancer mortality. Gut, 2019.
4.
National
Cancer
Institute.
Young-onset
colorectal
cancer.
5. Patel SG, et al. Colorectal cancer in young adults. J Gastrointest Oncol.
6. Vuik FE, et al. Increasing incidence of colorectal cancer in young adults. BMJ, 2019.
7. NCCN Clinical Practice Guidelines in Oncology – Colorectal Cancer Screening.
8. Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology,
2010.
