THE EFFECT OF LACTOBACILLUS ON CANCER CELLS AND ITS ANTICANCER POTENTIAL

Authors

  • Fayzullaeva Madina Bakhshillo kizi Author
  • Erkinova Mehrangiz Ulugʻbek qizi Author
  • Maxarova Moxinur Baxtiyor qizi Author
  • Sodiqova Nigoraxon Sodirjon qizi Author

Keywords:

Keywords:lactobacillus, anticancer effect, probiotics, cancer cells, apoptosis, immunomodulation, bioactive metabolites, colorectal cancer

Abstract

 
Annotation:  This  paper  explores  the  potential  anticancer  effects 
of Lactobacillus species  on  various  cancer  cell  types.  Recent  studies  have 
demonstrated that certain strains of Lactobacillus, widely known as probiotics, not only 
support gut health but may also exert anticancer activity through multiple mechanisms. 
These include modulation of the immune system, reduction of inflammation, induction 
of  apoptosis  in  cancer  cells,  and  inhibition  of  tumor  growth.  The  article  reviews 
experimental  findings  related  to  colorectal,  breast,  prostate,  and  other  cancers, 
highlighting the role of bioactive compounds produced by Lactobacillus, such as lactic 
acid and bacteriocins. These metabolites have shown promise in suppressing cancer 
cell  proliferation  and  promoting  programmed  cell  death.  The  findings  suggest 
that Lactobacillus strains  could  be  considered  as  potential  adjuncts  in  cancer 
prevention and therapy.  
Annotation:  This  paper  explores  the  potential  anticancer  effects 
of Lactobacillus species  on  various  cancer  cell  types.  Recent  studies  have 
demonstrated that certain strains of Lactobacillus, widely known as probiotics, not only 
support gut health but may also exert anticancer activity through multiple mechanisms. 
These include modulation of the immune system, reduction of inflammation, induction 
of  apoptosis  in  cancer  cells,  and  inhibition  of  tumor  growth.  The  article  reviews 
experimental  findings  related  to  colorectal,  breast,  prostate,  and  other  cancers, 
highlighting the role of bioactive compounds produced by Lactobacillus, such as lactic 
acid and bacteriocins. These metabolites have shown promise in suppressing cancer 
cell  proliferation  and  promoting  programmed  cell  death.  The  findings  suggest 
that Lactobacillus strains  could  be  considered  as  potential  adjuncts  in  cancer 
prevention and therapy. 

References

References:

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probiotic Lactobacillus casei and Lactobacillus rhamnosus GG decrease colon

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https://doi.org/10.1080/01635581.2012.700758

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4887.2010.00305.x

Published

2025-08-10

How to Cite

Fayzullaeva Madina Bakhshillo kizi, Erkinova Mehrangiz Ulugʻbek qizi, Maxarova Moxinur Baxtiyor qizi, & Sodiqova Nigoraxon Sodirjon qizi. (2025). THE EFFECT OF LACTOBACILLUS ON CANCER CELLS AND ITS ANTICANCER POTENTIAL . TADQIQOTLAR, 68(1), 7-10. https://scientific-jl.com/tad/article/view/26043