PIRIMIDIN HALQASI ISHTIROKIDA SINTEZ VA PIRIMIDINNING BIOLOGIK FAOLLIGI
Keywords:
Kalit so’zlar: 6-metil-5-(piridin-4-ilsulfanil), 58b va 59a, 60 IC50 qiymatlari, folilpoli-γ-glutamat.Abstract
Anotatsiya: Hozirgi kunda molekulasida azot geteroatomi saqlagan geterosiklik
birikmalar qishloq xo’jaligi, tibbiyot va farmatsiyada keng qo’llaniladi. Ayniqsa pirrol,
pirimidin, pteridin, purin, turli xil azollar shular jumlasidandir. Bu sinf birikmalaridagi
azot geteroatomining molekulada joylashishiga qarab ular turli xil ko’pyoqlama
reaksion qobiliyatlarni namoyon qilishadi. Buning natijasida inson organizmidagi turli
xil fermentlar bilan bog’ hosil qilish kabi xususiyatlarni ko’rsatishadi.
Kondensirlangan pirrolopirimidin-4-on hosilalari molekulasida pirrol halqasidan
tashqari, pirimidin bo’lagida 1- va 3-holatdagi azot atomi, 4-uglerod atomidagi
karbonil guruhi (C=O), ularga tutashgan polimetilen zanjirida uglerod atomlari
mavjudligi sababli turfa xil reaksion markazlarga ega.
References
1. Toshboyev F. N., Iskandar o’g’li M. S., Fayzullo o’g’li S. S. XITOZAN VA SUT
ZARDOBI BILAN OZIQLANTIRILGAN BROYLER JOʻJALARINING
BIOKIMYOVIY KOʻRSATKICHLARI //Ta'lim innovatsiyasi va integratsiyasi. –
2024. – Т. 14. – №. 1. – С. 78-80.
2. Nizomiddinovich T. F. et al. QON TOMIR KASALIKLARIDA ENOSNING
O’RNI: Yangi O'zbekiston taraqqiyotida tadqiqotlarni o'rni va rivojlanish omillari
//Yangi O'zbekiston taraqqiyotida tadqiqotlarni o'rni va rivojlanish omillari. – 2024.
– Т. 6. – №. 1. – С. 56-62.
3. Nizomiddinovich T. F. et al. EXPERIMENTAL MYOCARDIAL INFARCTION
LDH BILAN CORRECTION OF NATHIJALARI: Yangi O'zbekiston
taraqqiyotida tadqiqotlarni o'rni va rivojlanish omillari //Yangi O'zbekiston
taraqqiyotida tadqiqotlarni o'rni va rivojlanish omillari. – 2024. – Т. 6. – №. 1. – С.
63-68.
4. Normurot F. et al. Effect of the Number of Active Components of the Catalyst on
the Yield of the Product During the Synthesis of Vinyl Acetate From Ethylene and
Acetic Acid //Бюллетень науки и практики. – 2021. – Т. 7. – №. 4. – С. 301-311.
5. Байкулов А. К., Муртазаева Н. К., Тошбоев Ф. Н. ДИНАМИКА ВЛИЯНИЯ
ЛАКТАТДЕГИДРОГЕНАЗЫ ПРИ ЭКСПЕРИМЕНТАЛЬНОМ ИНФАРКТЕ
МИОКАРДА //World of Scientific news in Science. – 2024. – Т. 2. – №. 3. – С.
244-251.
6. Baxodirovich S. S., Nizomiddinovich T. F., Ergashboevna E. M. GАZ
АRАLАSHMАLАRINI NАZORАT QILIShNING TERMOKАTАLITIK USULI
//Journal of Universal Science Research. – 2024. – Т. 2. – №. 2. – С. 276-281.
7. Мусулмонов Н. и др. КИНЕТИКА СИНТЕЗА ЭТИЛАЦЕТАТА ИЗ
УКСУСНОЙ КИСЛОТЫ //Збірник наукових праць ΛΌГOΣ. – 2020. – С. 49-
54.
8. Normurot F., Firdavsiy B. The Effect of Catalytic Activity of Catalyst (Carrier)
Nature in the Synthesis of Vinyl Acetate //International Journal of Human
Computing Studies. – 2021. – Т. 3. – №. 10. – С. 16-19.
9. Тошбоев Ф. Н., Анваров Т. О., Изатуллаев С. А. ОПРЕДЕЛЕНИЕ PH СРЕДЫ
ЛЕКАРСТВЕННЫХ ВЕЩЕСТВ ПОТЕНЦИОМЕТРИЧЕСКИМ МЕТОДОМ
//World of Scientific news in Science. – 2023. – Т. 1. – №. 1. – С. 166-169.
10. Toshboyev F. N., Akhmadov J. Z., Eshonqulov Z. A. ETHYLENE
OXYACETYLATION REACTION KINETICS LEARN //Modern Scientific
Research International Scientific Journal. – 2024. – Т. 2. – №. 1. – С. 253-256.
11. Baykulov A. K., Toshboyev F. N., Akhmadov J. Z. BIOCHEMICAL AND
PHYSIOLOGICAL CHANGES IN PARASITE PARAMETERS IN THE HOST-
PARASITE RELATIONSHIP //Modern Scientific Research International
Scientific Journal. – 2024. – Т. 2. – №. 1. – С. 257-262.
12. Xudoyberdiyev I. I. et al. ETILEN VA SIRKA KISLOTADAN VINILASETAT
OLINISHI JARAYONINING FIZIK-KIMYOVIY ASOSLARI //Zamonaviy fan
va ta'lim yangiliklari xalqaro ilmiy jurnal. – 2023. – Т. 1. – №. 5. – С. 59-62.
13. Toshboyev F. N., Bobokulova S. A., Suyunova M. O. SYNTHESIS OF VINYL
ACETATE FROM ACETYLENE WITH THE PARTICIPATION OF A
NANOCATALYST AND STUDY OF ITS KINETICS //World of Scientific news
in Science. – 2024. – Т. 2. – №. 2. – С. 11-18.
14. Восканян П. С. Влияние содержания и соотношения активных компонентов
на активность и селективность катализатора синтеза винилацетата
газофазным ацетоксилированием этилена //Катализ в промышленности. –
2010. – №. 2. – С. 43-49.
15. Nizomiddinovich T. F., Abdimannonovich I. S., Zoirovich A. J. OF ORGANIC
SUBSTANCES BY THIN LAYER CHROMATOGRAPHIC METHOD //Ta'lim
innovatsiyasi va integratsiyasi. – 2024. – Т. 14. – №. 1. – С. 70-72.
16. Тошбоев Ф. Н., Ахмадов Д. З., Эшанкулов З. А. ДИНАМИКА
НИТРЕРГИЧЕСКОЙ СИСТЕМЫ ПРИ ГИПЕРХОЛЕСТЕРИНЕМИИ //Ta'lim
innovatsiyasi va integratsiyasi. – 2024. – Т. 14. – №. 1. – С. 73-77.
17. Toshboyev F. N. et al. SELECTIVITY OF YKS CATALYZATION IN THE
SYNTHESIS OF VINYL ACETATE FROM ETHYLENE AND ACETIC ACID
//World of Scientific news in Science. – 2023. – Т. 1. – №. 2. – С. 31-35.
18. Toshboyev F. N., Tashanov O. S., Izatullayev S. A. OZIQA TARKIBIDAGI
SPIRTLARNI OKSIDLANISH JARAYONINI MATIMATIK
MODILASHTIRISH ORQALI XISOBLASH //GOLDEN BRAIN. – 2023. – Т. 1.
– №. 28. – С. 117-120.
19. K. Bozorov, J. Zhao, H.A. Aisa, 1,2,3-Triazole-containing hybrids as leads in
medicinal chemistry: A recent overview, Bioorganic & Medicinal Chemistry, 27
(2019) 3511-3531.
20. B.C. Das, M. Adil Shareef, S. Das, N.K. Nandwana, Y. Das, M. Saito, L.M. Weiss,
Boron-Containing heterocycles as promising pharmacological agents, Bioorganic
& Medicinal Chemistry, 63 (2022) 116748.
21. H. Huo, G. Li, B. Shi, J. Li, Recent advances on synthesis and biological activities
of C-17 aza-heterocycle derived steroids, Bioorganic & Medicinal Chemistry, 69
(2022) 116882.
