RECURRENT APHTHOUS STOMATITIS IN RHEUMATOLOGY

Authors

  • Teshayeva Nozigul Ҳамидулло қизи Author

Abstract

 ABSTRACT. Recurrent aphthous stomatitis consists on recurring oral ulcers 
of unknown etiology. Oral ulcers may be different in number and size depending on 
the clinical presentation, which also determines the time needed for healing. Moreover, 
there are factors associated to outbreaks but not implicated in its etiopathogenesis. 
When oral aphthosis has a known etiology, it is not considered as recurrent aphthous 
stomatitis. The severity and the clinical presentation helps in the differential diagnosis. 
Treatment  is  symptomatic  in  recurrent  aphthous  stomatitis  while,  if  there  is  an 
underlying systemic disease, the treatment of such disease is need in addition to topical 
treatment. 

References

REFERENCES

1. Sánchez-Bernal J, Conejero C, Conejero R. Recurrent Aphthous Stomatitis. Actas

Dermosifiliogr (Engl Ed). 2020 Jul-Aug;111(6):471-480. [PubMed]

2. Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Wu YC, Sun A. Recurrent

aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic

deficiencies, and management. J Formos Med Assoc. 2019 Sep;118(9):1279-1289.

[PubMed]

3. Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral

Maxillofac Surg. 2008 Apr;46(3):198-206. [PubMed]

4. Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent

aphthous stomatitis: a consensus approach. J Am Dent Assoc. 2003

Feb;134(2):200-7. [PubMed]

5. Mimura MA, Hirota SK, Sugaya NN, Sanches JA, Migliari DA. Systemic treatment

in severe cases of recurrent aphthous stomatitis: an open trial. Clinics (Sao Paulo).

2009;64(3):193-8. [PMC free article] [PubMed]

6. Savage NW, Seymour GJ, Kruger BJ. Expression of class I and class II major

histocompatibility complex antigens on epithelial cells in recurrent aphthous

stomatitis. J Oral Pathol. 1986 Apr;15(4):191-5. [PubMed]

7. Hasan A, Childerstone A, Pervin K, Shinnick T, Mizushima Y, Van der Zee R,

Vaughan R, Lehner T. Recognition of a unique peptide epitope of the mycobacterial

and human heat shock protein 65-60 antigen by T cells of patients with recurrent

oral ulcers. Clin Exp Immunol. 1995 Mar;99(3):392-7. [PMC free article]

[PubMed]

8. Shohat-Zabarski R, Kalderon S, Klein T, Weinberger A. Close association of HLA-

B51 in persons with recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol.

1992 Oct;74(4):455-8. [PubMed]

9. Bazrafshani MR, Hajeer AH, Ollier WE, Thornhill MH. Recurrent aphthous

stomatitis and gene polymorphisms for the inflammatory markers TNF-alpha, TNF-

beta and the vitamin D receptor: no association detected. Oral Dis. 2002

Nov;8(6):303-7. [PubMed]

10. Mizuki N, Ohno S, Sato T, Ishihara M, Miyata S, Nakamura S, Naruse T, Mizuki

H, Tsuji K, Inoko H. Microsatellite polymorphism between the tumor necrosis

factor and HLA-B genes in Behçet's disease. Hum Immunol. 1995 Jun;43(2):129-

35. [PubMed]

11. Huling LB, Baccaglini L, Choquette L, Feinn RS, Lalla RV. Effect of stressful life

events on the onset and duration of recurrent aphthous stomatitis. J Oral Pathol Med.

2012 Feb;41(2):149-52. [PMC free article] [PubMed]

Published

2025-04-15

How to Cite

Teshayeva Nozigul Ҳамидулло қизи. (2025). RECURRENT APHTHOUS STOMATITIS IN RHEUMATOLOGY . TADQIQOTLAR, 60(1), 186-188. https://scientific-jl.com/tad/article/view/8935

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