THE ROLE OF VITAMIN B12 IN THE DEVELOPMENT OF HYPERANDROGENISM AND METHODS TO IMPROVE MODERN TREATMENT APPROACHES

Authors

  • Ashurova Nigora Gafurovna Author
  • Najimova Sumanbar Tulkinovna Author

Keywords:

Keywords: hyperandrogenism, vitamin B12, hormonal imbalance, polycystic ovary syndrome (PCOS), insulin resistance, metabolic syndrome, micronutrients, therapy.

Abstract

Hyperandrogenism is a clinical syndrome characterized by excessive production of androgen hormones in women, leading to various gynecological and endocrine disorders. Recent studies have highlighted the critical roles of vitamin B12 in metabolism, hormonal balance, and nervous system functioning. This article analyzes the pathogenesis of hyperandrogenism and the potential involvement of vitamin B12 in its development. Additionally, contemporary treatment methods are reviewed, with a focus on the role of vitamin B12 supplementation in enhancing therapeutic efficacy.

References

1. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nature Reviews Endocrinology. 2018;14(5):270-284.

2. Palomba S, et al. Metformin treatment in hyperandrogenic women: the role of B12 supplementation. Journal of Clinical Endocrinology & Metabolism. 2017;102(3):1123-1130.

3. Rehman HU. Role of vitamin B12 in metabolic syndrome and PCOS. Archives of Medical Research. 2019;50(5):371-379.

4. Azziz R. Diagnosis of hyperandrogenism in women: emerging technologies and therapeutic implications. Obstetrics and Gynecology Clinics. 2020;47(3):413-431.

5. WHO Guidelines on micronutrient supplementation in clinical practice, 2021.

6. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to PCOS. Fertil Steril. 2004;81(1):19-25.

7. Diamanti-Kandarakis E, et al. Insulin resistance and PCOS: mechanisms and implications. Endocrine Reviews. 2020;41(5):1-20.

Published

2025-06-03

How to Cite

Ashurova Nigora Gafurovna, & Najimova Sumanbar Tulkinovna. (2025). THE ROLE OF VITAMIN B12 IN THE DEVELOPMENT OF HYPERANDROGENISM AND METHODS TO IMPROVE MODERN TREATMENT APPROACHES. World Scientific Research Journal, 40(1), 155-157. https://scientific-jl.com/wsrj/article/view/18110