PHASES OF CHRONIC MYELOID LEUKEMIA AND EPIDEMIOLOGY IN UZBEKISTAN

Abstract

This article presents a comprehensive and detailed analysis of chronic myeloid leukemia (CML), focusing on its three well-defined clinical and laboratory phases: the chronic phase, accelerated phase, and blast crisis. Each phase is examined in terms of its pathophysiological characteristics, blast cell percentage, peripheral blood and bone marrow morphology, hematological parameters, and associated cytogenetic abnormalities. Clinical manifestations, including fatigue, splenomegaly, anemia, thrombocytopenia, bleeding tendencies, and extramedullary infiltration, are described for each stage. The study also discusses current therapeutic approaches, including targeted tyrosine kinase inhibitors, chemotherapy, and supportive care, along with the prognostic significance of phase identification in guiding patient management.