СОВРЕМЕННЫЕ АСПЕКТЫ ИММУННЫХ МЕХАНИЗМОВ В ПАТОГЕНЕЗЕ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ
##semicolon##
Ключевые слова: артериальная гипертензия, иммунитет, цитокины, эндотелий, сердечно-сосудистые заболевания.##article.abstract##
Резюме: В настоящем обзоре представлены данные современных научных исследований, свидетельствующие об участии иммунной системы в регуляции артериального давления, рассматриваются механизмы нейро-иммунной регуляции сосудистого тонуса, эндотелиальной дисфункции и модуляции цитокинового статуса в патогенезе артериальной гипертензии. Авторами сформулирован вывод о предикторах формирования артериальной гипертензии и причинно-следственной роли иммунных и воспалительных реакций организма.
##submission.citations##
1. Agita A., Alsagaff M.T. Inflammation, Immunity, and Hypertension. Acta MedIndones. 2017 Apr; 49(2):158-165. PMID: 28790231.
2. Amador C.A., Barrientos V., Pena J., et al. Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the down regulation of regulatory T lymphocytes. //Hypertension. 2014;63(4):797–803. [PubMed] [GoogleScholar].
3. Baghai T. C., Varallo-Bedarida G., Born C., Hдfner S., Schьle C., Eser D., et al. (2018). Classical risk factors and inflammatory biomarkers: One of the missing biological links between cardiovascular disease and major depressive disorder. //International Journal of Molecular Sciences, 19(6), 1740.
4. Calvillo L, Gironacci MM, Crotti L, Meroni PL, Parati G. Neuroimmune crosstalk in the pathophysiology of hypertension.// NatRevCardiol. 2019 Aug;16(8):476-490. doi: 10.1038/s41569-019-0178-1. PMID: 30894678.
5. Chatterjee P., Chiasson V.L., Seerangan G., Tobin R.P., Kopriva S.E., Newell-Rogers M.K., Mitchell B.M.: Cotreatment with interleukin 4 and interleukin 10 modulates immune cells and prevents hypertension in pregnant mice. //Am J Hypertens 28: 135–142, 2015 [PubMed] [Google Scholar]
6. Chavan S.S., Pavlov V.A., Tracey K.J. //Mechanisms and therapeutic relevance of neuro-immune communication. Immunity. 2017;46(6):927–42. https://doi.org/10.1016/j.immuni.2017.06. 008.
7. Chen K., Kolls J.K. (2017) Interluekin-17A (IL17A).// Gene 614:8–14
8. Drummond G.R., Vinh A., Guzik T.J., Sobey C.G. Immune mechanisms of hypertension. Nat Rev Immunol. 2019. State-of-the-art review of innate and adaptive immunity mechanisms of hypertension.
9. Edwards, N., Langford-Smith, A. W., Wilkinson, F. L., &Alexander, M. Y. (2018). Endothelial progenitor cells: New targets for therapeutics for inflammatory conditions with high cardiovascular risk. FrontiersinMedicine, 5, 200.
10. Godo S., Shimokawa H. Endothelial Functions.// ArteriosclerThrombVasc Biol. 2017 Sep;37(9):e108-e114. doi: 10.1161/ATVBAHA.117.309813. PMID: 28835487.
11. Guan X., Wang L., Liu Z., Guo X., Jiang Y., Lu Y., et al. (2016). miR-106a promotes cardiac hypertrophy by targeting mitofusin // Journal of Molecular and Cellular Cardiology, 99, 207–217.
12. Guzik T.J., Skiba D.S., Touyz R.M., Harrison D.G. The role of infiltrating immune cells in dysfunctional adipose tissue. Cardiovasc Res. 2017;113(9):1009–23. https://doi.org/10.1093/cvr/cvx108.
13. Han L., Dai L., Zhao Y.-F. Li, H.-Y., Liu O., Lan F., et al. (2018). CD40L promotes development of acute aortic dissection via induction of inflammation and impairment of endothelial cell function. Aging (Albany NY), 10(3), 371.
14. Harmon A, Cornelius D, Amaral L, Paige A, Herse F, Ibrahim T et al (2015) IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia. Hypertens Pregnancy 34:291–306
15. Harrison D.G. & Bernstein K.E. Inflammation and Immunity in Hypertension. Hypertension: A Companion to Braunwald’s Heart Disease 60–69 (2018). doi:10.1016/b978-0-323-42973-3.00007-x
16. Haybar H., & Zayeri, Z. D. (2017). The value of using polymorphisms in anti-platelet therapy. Frontiers in Biology, 12(5), 349–356.
17. Incalza M.A., D'Oria R., Natalicchio A., Perrini S., Laviola L., Giorgino F. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vascul Pharmacol. 2018 Jan;100:1-19. doi: 10.1016/j.vph.2017.05.005. Epub 2017 Jun 1. PMID: 28579545.
18. Jensen, H. A., & Mehta, J. L. (2016). Endothelial cell dysfunction as a novel therapeutic target in atherosclerosis . Expert Review of Cardiovascular Therapy, 14(9), 1021–1033.
19. Kim B.S., Park Y.J., Chung Y. (2016) Targeting IL-17 in autoimmunity and inflammation. ArchPharmRes 39:1537–1547
20. Lilly L.S. Braunwald’s heart disease: A textbook of cardiovascular medicine. Elsevier. 2015;10:935–53.
21. LimaV.V., Zemse S.M., Chiao C.W., Bomfim G.F.,Tostes R.C., Clinton R., Giachini F.R. (2016) Interleukin-10 limits increased blood pressure and vascular RhoA/Rho-kinase signaling in angiotensin IIinfused mice. LifeSci. 145:137–143
22. Marko L,, Kvakan H., Park J.K., Qadri F., Spallek B. Binger K.J. et al. (2012) Interferon-gamma signaling inhibition ameliorates angiotensin II-induced cardiac damage. Hypertension 60:1430–1436.
23. McMaster W.G, Kirabo A., Madhur M.S., Harrison D.G. Inflammation, immunity, and hypertensive end-organ damage. CircRes. 2015 Mar 13; 116(6):1022-33. doi: 10.1161/CIRCRESAHA.116.303697. PMID: 25767287; PMCID: PMC4535695.
24. Meza C.A., La Favor J.D., Kim D.H., Hickner R.C. Endothelial Dysfunction: Is There a Hyperglycemia-Induced Imbalance of NOX and NOS? Int J Mol Sci. 2019 Aug 2; 20(15):3775. doi: 10.3390/ijms20153775. PMID: 31382355; PMCID: PMC6696313.
25. Mikolajczyk T.P., Guzik T.J. Adaptive Immunity in Hypertension. CurrHypertens Rep. 2019 Jul 18; 21(9):68. doi: 10.1007/s11906-019-0971-6. PMID: 31321561; PMCID: PMC6647517.
26. Miller L. E. (2018). Methylsulfonylmethane decreases inflammatory response to tumor necrosis factor-α in cardiac cells.// American Journal of Cardiovascular Disease, 8(3), 31.
27. Morris G., Puri B.K., Olive L., Carvalho A., Berk M., Walder K., Gustad L.T., Maes M. Endothelial dysfunction in neuroprogressive disorders-causes and suggested treatments. BMCMed. 2020 Oct 19; 18(1):305. doi: 10.1186/s12916-020-01749-w. PMID: 33070778; PMCID: PMC7570030.
28. Navruzova Sh.I., Shodmonova N.K., Soliev A.U.
(2021) The significance of markers of immune
inflammation and indicators of metabolic
syndrome in the prognosis of complications
of arterial hypertension. NEW DAY IN MEDICINE, 3 (35), P. 166-171.
29. Nguyen H., Chiasson V.L., Chatterjee P., Kopriva S.E., Young K.J., Mitchell B.M. Interleukin-17 causes Rho-kinase-mediated endothelial dysfunction and hypertension. Cardiovasc Res. 2013;97(4):696–704. [PMCfree article] [PubMed] [Google Scholar].
30. Norlander A.E., Madhur M.S., Harrison D.G. The immunology of hypertension. J.Exp.Med. 2018;215(1):21–33. [PMCfree rticle] [PubMed] [Google Scholar].
31. Oparil S., Acelajado M.C., Bakris G.L., Berlowitz D.R., Cífková R., Dominiczak A.F., Grassi G., Jordan J., Poulter N.R., Rodgers A., Whelton P.K. Hypertension. Nat Rev Dis Primers. 2018 Mar 22; 4:18014. doi: 10.1038/nrdp.2018.14. PMID: 29565029; PMCID: PMC6477925.
32. Ordovas-Montanes J., Rakoff-Nahoum S., Huang S., Riol-Blanco L., Barreiro O., von Andrian U.H. The regulation of immunological processes by peripheral neurons in homeostasis and disease. //Trends Immunol. 2015;36(10):578–604. https://doi.org/10.1016/j. it.2015.08.007.
33. Perrotta M., Lembo G., Carnevale D. The Interactions of the Immune System and the Brain in Hypertension. CurrHypertensRep. 2018 Feb 24;20(1):7. doi: 10.1007/s11906-018-0808-8. PMID: 29478153.
34. Popa M., Tahir S., Elrod J., Kim S. H., Leuschner F., Kessler T., et al. (2018). Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell–platelet–monocyte interaction. Proceedings of the National Academy of Sciences of the United States of America, 115, E5556–E5565.
35. Ridker P.M., Everett B.M., Thuren T., MacFadyen J.G., Chang W.H., Ballantyne C. et al. (2017) Anti inflammatory therapy with canakinumab for atherosclerotic disease. N. Engl. J. Med. 377:1119–1131
36. Rodriguez-Iturbe B, Pons H, Johnson RJ (2017) Role of the immune system in hypertension. Physiol. Rev. 97:1127–1164.
37. Rodriguez-Iturbe B, Pons H, Johnson RJ (2017) Role of the immune system in hypertension. Physiol. Rev. 97:1127–1164.
38. Small H.Y., Migliarino S., Czesnikiewicz-Guzik M., Guzik T.J. Hypertension: Focus on autoimmunity and oxidative stress. Free Radic Biol Med. 2018 Sep; 125:104-115. doi: 10.1016/j.freeradbiomed.2018.05.085. Epub 2018 May 30. PMID: 29857140.
39. Sun B., Wang H., Zhang L., Yang X., Zhang M., Zhu X., Ji X., and Wang H.. 2017a Role of interleukin 17 in TGF-β signaling-mediated renal interstitial fibrosis. Cytokine. 10.1016/j.cyto.2017.10.015 [PubMed] [CrossRef] [GoogleScholar]
40. Trial J., Cieslik K. A., &Entman, M. L. (2016). Phosphocholine containing ligands direct CRP induction of M2 macrophage polarization independent of T cell polarization: Implication for chronic inflammatory states. Immunity, Inflammation and Disease, 4(3), 274–288.
41. Wei L.H., Huang X.R., Zhang Y., Li Y.Q., Chen H.Y., Heuchel R. et al. (2013) Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension. PLoS ONE 8:e70195
42. Wen Y, Crowley SD. Renal Effects of Cytokines in Hypertension. Adv Exp Med Biol. 2019; 1165:443-454. doi: 10.1007/978-981-13-8871-2_21. PMID: 31399978.
43. Wenzel U., Turner J.E., Krebs C., Kurts C., Harrison D.G., Ehmke H. Immune Mechanisms in Arterial Hypertension. //J. Am.Soc.Nephrol. 2016;27(3):677-686. doi:10.1681/ASN.2015050562
44. Yin J., Xia W., Zhang Y., Ding G., Chen L., Yang G., et al. (2018). Role of dihydroartemisinin in regulating prostaglandin E2 synthesis cascade and inflammation in endothelial cells.// Heart and Vessels, 33(11), 1411–1422.
45. Zhang C., Li Y., Wang C., Wu Y., Cui W., Miwa T., Sato S., Li H., Song W.C., Du J.: Complement 5a receptor mediates angiotensin II-induced cardiac inflammation and remodeling.// ArteriosclerThrombVasc Biol 34: 1240–1248, 2014 [PubMed] [Google Scholar
46. Zhang C., Li Y., Wang C., Wu Y., Du J.: Antagonist of C5aR prevents cardiac remodeling in angiotensin II-induced hypertension. //AmJHypertens 27: 857–864, 2014 [PubMed] [GoogleScholar]
