XITOZAN-1,2,4-TRIAZOL-3D METALL KOMPLEKSLARINING MIKROBLARGA QARSHI XUSUSIYATLARI: YANGI BIRIKMALAR SINTEZI VA QO'LLANILISHI
Keywords:
Kalit so‘zlar:xitozan, 1,2,4-triazol, metall komplekslari, mikroblarga qarshi faollik, koordinatsion birikmalar, Co(II), Cu(II), Zn(II), spektroskopiya, biofaollik, sintez usullari, triazol ligandlari, zamburug‘larga qarshi ta’sir, virusga qarshi xususiyatlar, biomembrana, oksidlovchi stressAbstract
Annotatsiya:Ushbu maqolada xitozan asosida 1,2,4-triazol hosilalari bilan
sintez qilingan o‘tuvchi metall komplekslarining (Fe(II), Co(II), Ni(II), Cu(II), Zn(II),
Mn(II), Cr(III)) sintezi, koordinatsion tuzilmalari, spektroskopik xususiyatlari va
mikroblarga qarshi faolligi tahlil qilingan. Komplekslar Shiff asoslari, "click" kimyosi
va to‘g‘ridan-to‘g‘ri bog‘lash kabi usullar bilan hosil qilingan bo‘lib, ularning IR, UV-
Vis, FTIR, XRD, SEM, TEM va boshqa instrumental usullar orqali tuzilmalari
aniqlangan. Tadqiqotlar natijasida Co(II), Cu(II) va Zn(II) komplekslarining
bakteriyalarga, zamburug‘larga va ayrim hollarda viruslarga qarshi yuqori faollikka
ega ekani aniqlangan. Xususan, bu komplekslar biomembrana bilan elektrostatik ta’sir,
ferment inhibatsiyasi va oksidlovchi stress mexanizmlari orqali mikroorganizmlar
faoliyatini susaytiradi. Mazkur moddalarning farmatsevtika va agrotexnologiyada
qo‘llanilishi istiqbolli hisoblanadi.
References
Foydalanilgan adabiyotlar ro’yxati:
1. Haddad, R., Yousif, E., & Ahmed, A. (2013a). Synthesis and characterization of
transition metal complexes of 4-Amino-5-pyridyl-4H-1,2,4-triazole-3-thiol.
SpringerPlus, 2(1). https://doi.org/10.1186/2193-1801-2-510
2. Haddad, R., Yousif, E., & Ahmed, A. (2013b). Synthesis and characterization of
transition metal complexes of 4-Amino-5-pyridyl-4H-1,2,4-triazole-3-thiol.
SpringerPlus, 2(1). https://doi.org/10.1186/2193-1801-2-510
3. Ismiyarto, I., Saputri, N. W., Rahmatia, L. Z., Sarjono, P. R., Ngadiwiyana, N.,
Prasetya, N. B. A., & Bima, D. N. (2021, June 4). Synthesis of MN(II) Complexes-
Carboxymethyl chitosan Schiff base salicylaldehyde and antibacterial activity.
Ismiyarto | Jurnal Kimia Valensi.
https://journal.uinjkt.ac.id/index.php/valensi/article/view/19866
4. Kazeminejad, Z., Marzi, M., Shiroudi, A., Kouhpayeh, S. A., Farjam, M., &
Zarenezhad, E. (2022). Novel 1, 2, 4-Triazoles as antifungal agents. BioMed
Research International, 2022, 1–39. https://doi.org/10.1155/2022/4584846
5. Kumar, R. (n.d.). triazole. Scribd.
https://ru.scribd.com/document/696078954/triazole
6. Liu, W., Qin, Y., Liu, S., Xing, R., Yu, H., Chen, X., Li, K., & Li, P. (2018a).
Synthesis of C-coordinated O-carboxymethyl chitosan metal complexes and
evaluation of their antifungal activity. Scientific Reports, 8(1).
https://doi.org/10.1038/s41598-018-23283-9
7. Liu, W., Qin, Y., Liu, S., Xing, R., Yu, H., Chen, X., Li, K., & Li, P. (2018b).
Synthesis of C-coordinated O-carboxymethyl chitosan metal complexes and
evaluation of their antifungal activity. Scientific Reports, 8(1).
https://doi.org/10.1038/s41598-018-23283-9
8. Nie, J., Wang, Z., & Hu, Q. (2016). Chitosan hydrogel structure modulated by metal
ions. Scientific Reports, 6(1). https://doi.org/10.1038/srep36005
9. Rathinam, S., Magdadaro, R., Hjálmarsdóttir, M. Á., & Másson, M. (2024). Water-
Soluble quaternary and protonable basic chitotriazolans: synthesis by click
chemistry conversion of chitosan azides and investigation of antibacterial activity.
Journal of Functional Biomaterials, 15(3), 63. https://doi.org/10.3390/jfb15030063
10. Sarwar, A., Katas, H., Samsudin, S. N., & Zin, N. M. (2015). Regioselective
sequential modification of Chitosan via Azide-Alkyne Click reaction: synthesis,
characterization, and antimicrobial activity of chitosan derivatives and
nanoparticles. PLoS ONE, 10(4), e0123084.
https://doi.org/10.1371/journal.pone.0123084
11. Vala, D. P., Vala, R. M., & Patel, H. M. (2022). Versatile synthetic platform for
1,2,3-Triazole chemistry. ACS Omega, 7(42), 36945–36987.
https://doi.org/10.1021/acsomega.2c04883
12. Wang, X., Du, Y., Fan, L., Liu, H., & Hu, Y. (2005). Chitosan- metal complexes as
antimicrobial agent: Synthesis, characterization and Structure-activity study.
Polymer Bulletin, 55(1–2), 105–113. https://doi.org/10.1007/s00289-005-0414-1
