KIDNEY DISEASES AND THEIR PATHOGENESIS: A SCIENTIFIC OVERVIEW
Keywords:
Keywords: Kidney diseases, pathogenesis, glomerulonephritis, chronic kidney disease, nephropathy, renal failure, inflammation, fibrosisAbstract
Abstract: Kidney diseases encompass a broad spectrum of disorders affecting
the structure and function of the kidneys. Understanding the pathogenesis of these
diseases is essential for effective diagnosis, treatment, and prevention. This article
reviews common kidney diseases, including glomerulonephritis, diabetic nephropathy,
and chronic kidney disease (CKD), and discusses the molecular and cellular
mechanisms underlying their development and progression.
References
References
1. Nangaku, M. (2006). Pathogenesis of chronic kidney disease. Clin Exp Nephrol,
10(4), 257–265. https://doi.org/10.1007/s10157-006-0450-7
2. Pichler, R., Afkarian, M., Dieter, B. P., & Tuttle, K. R. (2017). Immunity and
inflammation in diabetic kidney disease: Translating mechanisms to biomarkers
and treatment targets. American Journal of Physiology-Renal Physiology, 312(5),
F716–F731. https://doi.org/10.1152/ajprenal.00342.2016
3. Liu, Y. (2011). Cellular and molecular mechanisms of renal fibrosis. Nature
Reviews Nephrology, 7(12), 684–696. https://doi.org/10.1038/nrneph.2011.149
4. Levey, A. S., Coresh, J. (2012). Chronic kidney disease. The Lancet, 379(9811),
165–180. https://doi.org/10.1016/S0140-6736(11)60178-5
5. Kang, H. M., Ahn, S. H., Choi, P., Ko, Y. A., Han, S., Chinga, F., ... &
Humphreys, B. D. (2015). Defective fatty acid oxidation in renal tubular epithelial
cells has a key role in kidney fibrosis development. Nature Medicine, 21(1), 37–46.
