NEPHROLYSIS PATHOPHYSIOLOGY: MECHANISMS AND CLINICAL IMPLICATIONS
Abstract
Nephrolysis is a surgical procedure involving the dissection of perinephric
adhesions surrounding the kidney, often performed to treat obstructive uropathy or
chronic flank pain caused by fibrosis. Although frequently successful, the underlying
pathophysiological mechanisms leading to the need for nephrolysis—such as chronic
inflammation, retroperitoneal fibrosis, and ischemia—are complex and multifactorial.
This article explores the biological and molecular pathways that contribute to
perinephric adhesion formation and reviews the clinical consequences and outcomes
of nephrolysis.
References
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