GIPERBILIRUBINEMIYA FONIDA ESEFALOPATIYA XAVFINI ANIQLOVCHI KLINIK-LABORATOR MEZONLAR.
Keywords:
Kalit so‘zlar: giperbilirubinemiya, bilirubinli ensefalopatiya, klinik mezonlar, laborator ko‘rsatkichlar, NEYROTOKSIKLIK, yangi tug‘ilgan chaqaloqAbstract
Annotatsiya: Ushbu tezisda yangi tug‘ilgan chaqaloqlarda giperbilirubinemiya
fonida bilirubinli ensefalopatiya (kernikterus) rivojlanish xavfini baholashda
qo‘llaniladigan asosiy klinik va laborator mezonlar tahlil qilinadi. Xususan,
homiladorlik va tug‘ruq jarayonining kechishi, tug‘ilgan vaqtdagi tana vazni, APGAR
balining past bo‘lishi, gemolitik kasalliklar, infektsion holatlar va qon guruhlari
nizoligi kabi klinik ko‘rsatkichlar bilan bir qatorda umumiy bilirubin, erkin
(konjugatsiyalanmagan) bilirubin, albumin darajalari, bilirubin/albumin nisbati hamda
transkranial dopplerografiya natijalari asosida ensefalopatiya rivojlanish ehtimoli
aniqlashning ilmiy asoslari bayon etiladi.
References
Foydalangan adabiyotlar ro‘yxati
1. Smith J., Brown R. Giperbilirubinemiya va neonatal ensefalopatiya: klinik
ko‘rsatkichlar tahlili. Pediatrics International, 2019; 61(2): 115–120. (116-bet)
2. Lee K. Neonatal jaundice: pathophysiology and risk assessment. Journal of
Neonatal Medicine, 2022; 13(1): 45–50. (47-bet)
3. Gartner L., Lee J. Bilirubin toxicity and kernicterus. Clinical Neonatology, 2020;
7(3): 180–187. (183-bet)
4. Kim S., Park H. Bilirubin/albumin ratio as a predictor of encephalopathy.
Neonatal Research, 2021; 12(4): 292–298. (295-bet)
5. Huang A. Transcranial Doppler evaluation in hyperbilirubinemia. Journal of
Neonatal Imaging, 2020; 5(2): 68–73. (71-bet)
6. Ibrahim Y. Early neuroimaging markers of bilirubin encephalopathy. Neonatal
Neurology, 2021; 9(1): 21–28. (25-bet)
7. Chen L., Wu Z. Changes in coagulation parameters in severe neonatal
hyperbilirubinemia. Scientific Reports, 2022; 12: 1521–1528. (1525-bet)
8. Wilson M. Clinical risk factors of bilirubin encephalopathy. European Journal of
Pediatrics, 2019; 178(6): 841–847. (844-bet)
9. Anderson P., Cho J. Hemolytic disease and kernicterus outcomes. Archives of
Neonatal Medicine, 2020; 15(2): 90–96. (93-bet)
10. Luo Z. Serum biomarkers in predicting neonatal kernicterus. Biomedical Journal,
2021; 44(5): 735–741. (739-bet)
